Researchers at the University of Pittsburgh found that radiofrequency ablation (RFA) combined with an immune checkpoint inhibitor resulted in a stronger antitumor immunity with extended survival in human samples of primary colon tumor with liver metastasis and mice models of the disease.
The findings, titled “PD-1 Blockade Boosts Radiofrequency Ablation–Elicited Adaptive Immune Responses against Tumor,“ were published in Clinical Cancer Research , a journal of the American Association for Cancer Research.
Colorectal cancer is a disease causing abnormal growth of cells found in the lining of the colon or rectum, largely as a result of genetic mutations. The spread of the tumor cells to other parts of the body, mostly to the liver, is called metastasis of colorectal cancer.
“Liver is the most common site of colorectal cancer metastasis, and
about 20 percent of colorectal cancer patients have liver metastases at
the time of diagnosis [synchronous liver metastases],” Binfeng Lu, Ph.D., an associate professor in the Department of Immunology at the University of Pittsburgh, said in a press release.
After colorectal cancer patients are diagnosed with liver metastasis,
the best alternative treatment to surgery is RFA, especially for
patients with smaller size liver nodules. The procedure uses imaging
guidance to position a needle electrode through the skin into the liver
tumor, where medium frequency alternating currents (350–500 kHz) pass
through the electrode to induce heat that destroys tumor cells. However,
RFA has little effect in stopping cancer from progressing, so
researchers have investigated the immune-suppressive mechanisms limiting
the efficiency of RFA.
Read the full article here: https://coloncancernewstoday.com/2016/03/28/adding-immunotherapy-to-rfa-may-benefit-colorectal-cancer-patients-with-liver-metastasis/

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